Most all MMORPGs have a single area with the most activity, social wise.
Where do you think that will be in DEO? Of course, it's too early to name the city as we only know one as of yet.
What do you think the activity will be based around? Trading, resource gathering, what?
During the early stages of the game you will probably find that the Founder's Guild will be the central hub as it sounds like that's where lots of convenient NPCs and resources will be (which would also draw in trading). Once the player base grows to a size where a decent percentage of the player base are non-founders then a town with most of the needed commodities, maybe even Proem from what I can see, will be the central hub.
Rated number 1 in Dragon Eye Online.
Either the founder’s guild for experienced players or the most central city for the general public. Of course we have no idea of what awaits us in DEO, but it is fun to hypothesize.